D-strand perturbation and amyloid propensity in beta-2 microglobulin
نویسندگان
چکیده
منابع مشابه
Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry†
Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry † In vivo beta-2 microglobulin (b 2 m) forms amyloid fibrils that are associated with the disease dialysis-related amyloidosis. Here, electrospray ionisation-ion mobility spectrometry-mass spectrometry has been used to compare the oligomers formed from wild-type b 2 m with those forme...
متن کاملSERUM IgE AND BETA 2 MICROGLOBULIN LEVELS AFTER MYOCARDIAL INFARCTION
Serum IgE and beta 2 microglobulin levels were determined in 31 patients suffering from acute myocardial infarction and 30 patients with other forms of ischemic heart disease. The levels of these parameters were studied on the first, third and seventh day after the onset of disease. The immunological method used for the determinations was ELISA Patients with myocardial infarction showed an...
متن کاملSimulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin.
Amyloid fibrils formed from unrelated proteins often share morphological similarities, suggesting common biophysical mechanisms for amyloidogenesis. Biochemical studies of human beta-2 microglobulin (beta2M) have shown that its transition from a water-soluble protein to insoluble aggregates can be triggered by low pH. Additionally, biophysical measurements of beta2M using NMR have identified re...
متن کاملInsights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c3mb70420c Click here for additional data file.
In vivo beta-2 microglobulin (β2m) forms amyloid fibrils that are associated with the disease dialysis-related amyloidosis. Here, electrospray ionisation-ion mobility spectrometry-mass spectrometry has been used to compare the oligomers formed from wild-type β2m with those formed from a variant of the protein containing a single point mutation in the D strand, H51A, during in vitro fibril assem...
متن کاملBeta-2-Microglobulin in Autism Spectrum Disorders
Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental diseases of unknown etiology. There are no biological markers for ASD and current diagnosis is based on behavioral criteria. Recent data has shown that MHC I, a compound involved in adaptive immune function, is also involved in neurodevelopment, synaptic plasticity and behavior. It has been suggested that altered MHC I express...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2011
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2011.08157.x